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Ferroptosis at the crossroads of cancer-acquired drug resistance and immune evasion
Annexin V binds phosphatidylserines that translocate to the outer leaflet of the membrane during early apoptosis 61 , whereas 7-AAD is a membrane-impermeable DNA dye that labels cells with compromised membrane integrity, identifying cells undergoing lytic forms of cell death such as necrosis, secondary necrosis and pyroptosis 62,63
Titusville, NJ: Janssen Pharmaceuticals, Inc
Int J Biol Sci
was also testified in HepG2 and HepaRG cells by culturing with 30 mM APAP (Choi et al., 2017)
It is a protective agent
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